高被引论文TOP30

1. Gradient-based learning applied to document recognition

被引: 58239 | 年份: 1998 | 语言: en
期刊: Proceedings of the IEEE
作者: Yann LeCun, Léon Bottou, Yoshua Bengio, Patrick Haffner
DOI: https://doi.org/10.1109/5.726791
摘要: Multilayer neural networks trained with the back-propagation algorithm constitute the best example of a successful gradient based learning technique. Given an appropriate network architecture, gradient-based learning algorithms can be used to synthesize a complex decision surface that can classify high-dimensional patterns, such as handwritten characters, with minimal preprocessing. This paper reviews various methods applied to handwritten character recognition and compares them on a standard handwritten digit recognition task. Convolutional neural networks, which are specifically designed to deal with the variability of 2D shapes, are shown to outperform all other techniques. Real-life document recognition systems are composed of multiple modules including field extraction, segmentation r

2. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

被引: 32248 | 年份: 2015 | 语言: en
期刊: Genetics in Medicine
作者: Sue Richards, Nazneen Aziz, Sherri J. Bale, David Bick, Soma Das
DOI: https://doi.org/10.1038/gim.2015.30
摘要:

3. QUANTUM ESPRESSO: a modular and open-source software project for quantum simulations of materials

被引: 28838 | 年份: 2009 | 语言: en
期刊: Journal of Physics Condensed Matter
作者: Paolo Giannozzi, Stefano Baroni, Nicola Bonini, Matteo Calandra, Roberto Car
DOI: https://doi.org/10.1088/0953-8984/21/39/395502
摘要: QUANTUM ESPRESSO is an integrated suite of computer codes for electronic-structure calculations and materials modeling, based on density-functional theory, plane waves, and pseudopotentials (norm-conserving, ultrasoft, and projector-augmented wave). The acronym ESPRESSO stands for opEn Source Package for Research in Electronic Structure, Simulation, and Optimization. It is freely available to researchers around the world under the terms of the GNU General Public License. QUANTUM ESPRESSO builds upon newly-restructured electronic-structure codes that have been developed and tested by some of the original authors of novel electronic-structure algorithms and applied in the last twenty years by some of the leading materials modeling groups worldwide. Innovation and efficiency are still its mai

4. The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

被引: 27883 | 年份: 2009 | 语言: en
期刊: PLoS Medicine
作者: Alessandro Liberati, Douglas G. Altman, Jennifer Tetzlaff, Cynthia D. Mulrow, Peter C Gøtzsche
DOI: https://doi.org/10.1371/journal.pmed.1000100
摘要: Systematic reviews and meta-analyses are essential to summarize evidence relating to efficacy and safety of health care interventions accurately and reliably. The clarity and transparency of these reports, however, is not optimal. Poor reporting of systematic reviews diminishes their value to clinicians, policy makers, and other users.Since the development of the QUOROM (QUality Of Reporting Of Meta-analysis) Statement–a reporting guideline published in 1999–there have been several conceptual, methodological, and practical advances regarding the conduct and reporting of systematic reviews and meta-analyses. Also, reviews of published systematic reviews have found that key information about these studies is often poorly reported. Realizing these issues, an international group that include

5. GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers

被引: 26829 | 年份: 2015 | 语言: en
期刊: SoftwareX
作者: M Abraham, Teemu J. Murtola, Roland Schulz, Szilárd Páll, Jeremy C. Smith
DOI: https://doi.org/10.1016/j.softx.2015.06.001
摘要: GROMACS is one of the most widely used open-source and free software codes in chemistry, used primarily for dynamical simulations of biomolecules. It provides a rich set of calculation types, preparation and analysis tools. Several advanced techniques for free-energy calculations are supported. In version 5, it reaches new performance heights, through several new and enhanced parallelization algorithms. These work on every level; SIMD registers inside cores, multithreading, heterogeneous CPU–GPU acceleration, state-of-the-art 3D domain decomposition, and ensemble-level parallelization through built-in replica exchange and the separate Copernicus framework. The latest best-in-class compressed trajectory storage format is supported.

6. Rayyan—a web and mobile app for systematic reviews

被引: 24705 | 年份: 2016 | 语言: en
期刊: Systematic Reviews
作者: Mourad Ouzzani, Hossam M. Hammady, Zbys Fedorowicz, Ahmed K. Elmagarmid
DOI: https://doi.org/10.1186/s13643-016-0384-4
摘要: BACKGROUND: Synthesis of multiple randomized controlled trials (RCTs) in a systematic review can summarize the effects of individual outcomes and provide numerical answers about the effectiveness of interventions. Filtering of searches is time consuming, and no single method fulfills the principal requirements of speed with accuracy. Automation of systematic reviews is driven by a necessity to expedite the availability of current best evidence for policy and clinical decision-making. We developed Rayyan ( http://rayyan.qcri.org ), a free web and mobile app, that helps expedite the initial screening of abstracts and titles using a process of semi-automation while incorporating a high level of usability. For the beta testing phase, we used two published Cochrane reviews in which included stu

7. The Nature of the Firm

被引: 23425 | 年份: 1937 | 语言: en
期刊: Economica
作者: Ronald H. Coase
DOI: https://doi.org/10.1111/j.1468-0335.1937.tb00002.x
摘要: Economic theory has suffered in the past from a failure to state clearly its assumptions. Economists in building up a theory have often omitted to examine the foundations on which it was erected. This examination is, however, essential not only to prevent the misunderstanding and needless controversy which arise from a lack of knowledge of the assumptions on which a theory is based, but also because of the extreme importance for economics of good judgment in choosing between rival sets of assumptions. For instance, it is suggested that the use of the word “firm” in economics may be different from the use of the term by the “plain man.”11 Joan Robinson, Economics is a Serious Subject, p. 12. Since there is apparently a trend in economic theory towards starting analysis with the individual f

8. Distribution of the Estimators for Autoregressive Time Series with a Unit Root

被引: 22979 | 年份: 1979 | 语言: en
期刊: Journal of the American Statistical Association
作者: David A. Dickey, Wayne A. Fuller
DOI: https://doi.org/10.1080/01621459.1979.10482531
摘要: Abstract Let n observations Y 1, Y 2, ···, Y n be generated by the model Y t = pY t−1 + e t , where Y 0 is a fixed constant and {e t } t-1 n is a sequence of independent normal random variables with mean 0 and variance σ2. Properties of the regression estimator of p are obtained under the assumption that p = ±1. Representations for the limit distributions of the estimator of p and of the regression t test are derived. The estimator of p and the regression t test furnish methods of testing the hypothesis that p = 1.

9. The qualitative content analysis process

被引: 22276 | 年份: 2008 | 语言: en
期刊: Journal of Advanced Nursing
作者: Satu Elo, Helvi Kyngäs
DOI: https://doi.org/10.1111/j.1365-2648.2007.04569.x
摘要: AIM: This paper is a description of inductive and deductive content analysis. BACKGROUND: Content analysis is a method that may be used with either qualitative or quantitative data and in an inductive or deductive way. Qualitative content analysis is commonly used in nursing studies but little has been published on the analysis process and many research books generally only provide a short description of this method. DISCUSSION: When using content analysis, the aim was to build a model to describe the phenomenon in a conceptual form. Both inductive and deductive analysis processes are represented as three main phases: preparation, organizing and reporting. The preparation phase is similar in both approaches. The concepts are derived from the data in inductive content analysis. Deductive co

10. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

被引: 19240 | 年份: 2020 | 语言: en
期刊: The Lancet
作者: Theo Vos, Stephen S Lim, Cristiana Abbafati, Kaja Abbas, Mohammad Abbasi
DOI: https://doi.org/10.1016/s0140-6736(20)30925-9
摘要: BACKGROUND: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. METHODS: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses

11. The FAIR Guiding Principles for scientific data management and stewardship

被引: 17793 | 年份: 2016 | 语言: en
期刊: Scientific Data
作者: Mark D. Wilkinson, Michel Dumontier, IJsbrand Jan Aalbersberg, Gabrielle Appleton, Myles Axton
DOI: https://doi.org/10.1038/sdata.2016.18
摘要: There is an urgent need to improve the infrastructure supporting the reuse of scholarly data. A diverse set of stakeholders-representing academia, industry, funding agencies, and scholarly publishers-have come together to design and jointly endorse a concise and measureable set of principles that we refer to as the FAIR Data Principles. The intent is that these may act as a guideline for those wishing to enhance the reusability of their data holdings. Distinct from peer initiatives that focus on the human scholar, the FAIR Principles put specific emphasis on enhancing the ability of machines to automatically find and use the data, in addition to supporting its reuse by individuals. This Comment is the first formal publication of the FAIR Principles, and includes the rationale behind them,

12. SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

被引: 17121 | 年份: 2017 | 语言: en
期刊: Scientific Reports
作者: Antoine Daina, Olivier Michielin, Vincent Zoete
DOI: https://doi.org/10.1038/srep42717
摘要: To be effective as a drug, a potent molecule must reach its target in the body in sufficient concentration, and stay there in a bioactive form long enough for the expected biologic events to occur. Drug development involves assessment of absorption, distribution, metabolism and excretion (ADME) increasingly earlier in the discovery process, at a stage when considered compounds are numerous but access to the physical samples is limited. In that context, computer models constitute valid alternatives to experiments. Here, we present the new SwissADME web tool that gives free access to a pool of fast yet robust predictive models for physicochemical properties, pharmacokinetics, drug-likeness and medicinal chemistry friendliness, among which in-house proficient methods such as the BOILED-Egg, i

13. A Survey of Corporate Governance

被引: 16233 | 年份: 1997 | 语言: en
期刊: The Journal of Finance
作者: Andrei Shleifer, Robert W. Vishny
DOI: https://doi.org/10.1111/j.1540-6261.1997.tb04820.x
摘要: ABSTRACT This article surveys research on corporate governance, with special attention to the importance of legal protection of investors and of ownership concentration in corporate governance systems around the world.

14. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science

被引: 14843 | 年份: 2009 | 语言: en
期刊: Implementation Science
作者: Laura J. Damschroder, David C. Aron, Rosalind E. Keith, Susan Kirsh, J Alexander
DOI: https://doi.org/10.1186/1748-5908-4-50
摘要: BACKGROUND: Many interventions found to be effective in health services research studies fail to translate into meaningful patient care outcomes across multiple contexts. Health services researchers recognize the need to evaluate not only summative outcomes but also formative outcomes to assess the extent to which implementation is effective in a specific setting, prolongs sustainability, and promotes dissemination into other settings. Many implementation theories have been published to help promote effective implementation. However, they overlap considerably in the constructs included in individual theories, and a comparison of theories reveals that each is missing important constructs included in other theories. In addition, terminology and definitions are not consistent across theories.

15. Dynamic capabilities: what are they?

被引: 14446 | 年份: 2000 | 语言: en
期刊: Strategic Management Journal
作者: Kathleen M. Eisenhardt, Jeffrey A. Martin
DOI: https://doi.org/10.1002/1097-0266(200010/11)21:10/11<1105::aid-smj133>3.0.co;2-e
摘要: This paper focuses on dynamic capabilities and, more generally, the resource-based view of the firm. We argue that dynamic capabilities are a set of specific and identifiable processes such as product development, strategic decision making, and alliancing. They are neither vague nor tautological. Although dynamic capabilities are idiosyncratic in their details and path dependent in their emergence, they have significant commonalities across firms (popularly termed ‘best practice’). This suggests that they are more homogeneous, fungible, equifinal, and substitutable than is usually assumed. In moderately dynamic markets, dynamic capabilities resemble the traditional conception of routines. They are detailed, analytic, stable processes with predictable outcomes. In contrast, in high-velocity

16. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

被引: 14264 | 年份: 2012 | 语言: en
期刊: The Lancet
作者: Rafael Lozano, Mohsen Naghavi, Kyle J Foreman, Stephen S Lim, Kenji Shibuya
DOI: https://doi.org/10.1016/s0140-6736(12)61728-0
摘要:

17. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

被引: 14044 | 年份: 2018 | 语言: en
期刊: The Lancet
作者: Spencer L James, Degu Abate, Kalkidan Hassen Abate, Solomón Mequanente Abay, Cristiana Abbafati
DOI: https://doi.org/10.1016/s0140-6736(18)32279-7
摘要: BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world’s population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies,

18. Sarcopenia: revised European consensus on definition and diagnosis

被引: 14003 | 年份: 2018 | 语言: en
期刊: Age and Ageing
作者: Alfonso J. Cruz‐Jentoft, Gülistan Bahat, Jürgen M. Bauer, Yves Boirie‌, Olivier Bruyère
DOI: https://doi.org/10.1093/ageing/afy169
摘要: Background: in 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying and caring for people with sarcopenia. In early 2018, the Working Group met again (EWGSOP2) to update the original definition in order to reflect scientific and clinical evidence that has built over the last decade. This paper presents our updated findings. Objectives: to increase consistency of research design, clinical diagnoses and ultimately, care for people with sarcopenia. Recommendations: sarcopenia is a muscle disease (muscle failure) rooted in adverse muscle changes that accrue across a lifetime; sarcopenia is common among adults of older age but can also occur earlier in life. In this updated consensus paper on sarco

19. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

被引: 13547 | 年份: 2017 | 语言: en
期刊: The Lancet
作者: Theo Vos, Amanuel Alemu Abajobir, Kalkidan Hassen Abate, Cristiana Abbafati, Kaja Abbas
DOI: https://doi.org/10.1016/s0140-6736(17)32154-2
摘要: BACKGROUND: As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. METHODS: We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between incidence, prevalence, remission, and cause of death rates for each condition. For some causes, we used altern

20. UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

被引: 13334 | 年份: 2015 | 语言: en
期刊: PLoS Medicine
作者: Cathie Sudlow, John Gallacher, Naomi E. Allen, Valerie Beral, Paul R. Burton
DOI: https://doi.org/10.1371/journal.pmed.1001779
摘要: Cathie Sudlow and colleagues describe the UK Biobank, a large population-based prospective study, established to allow investigation of the genetic and non-genetic determinants of the diseases of middle and old age.

21. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation

被引: 13178 | 年份: 2015 | 语言: en
期刊: BMJ
作者: Larissa Shamseer, David Moher, Mike Clarke, Davina Ghersi, A. Liberati
DOI: https://doi.org/10.1136/bmj.g7647
摘要: Protocols of systematic reviews and meta-analyses allow for planning and documentation of review methods, act as a guard against arbitrary decision making during review conduct, enable readers to assess for the presence of selective reporting against completed reviews, and, when made publicly available, reduce duplication of efforts and potentially prompt collaboration. Evidence documenting the existence of selective reporting and excessive duplication of reviews on the same or similar topics is accumulating and many calls have been made in support of the documentation and public availability of review protocols. Several efforts have emerged in recent years to rectify these problems, including development of an international register for prospective reviews (PROSPERO) and launch of the fir

22. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

被引: 12997 | 年份: 2021 | 语言: en
期刊: European Heart Journal
作者: Theresa A. McDonagh, Marco Metra, Marianna Adamo, Roy S. Gardner, Andreas Baumbach
DOI: https://doi.org/10.1093/eurheartj/ehab368
摘要: The ESC Guidelines represent the views of the ESC and were produced after careful consideration of the scientific and medical knowledge and the evidence available at the time of their publication.The ESC is not responsible in the event of any contradiction, discrepancy and/or ambiguity between the ESC Guidelines and any other official recommendations or guidelines issued by the relevant public health authorities, in particular in relation to good use of healthcare or therapeutic strategies.Health professionals are encouraged to take the ESC Guidelines fully into account when exercising their clinical judgment, as well as in the determination and the implementation of preventive, diagnostic or therapeutic medical strategies; however, the ESC Guidelines do not override, in any way whatsoever

23. Bioconductor: open software development for computational biology and bioinformatics

被引: 12526 | 年份: 2004 | 语言: en
期刊: Genome biology
作者: Robert Gentleman, Vincent J. Carey, Douglas M. Bates, Ben Bolstad, Marcel Dettling
DOI: https://doi.org/10.1186/gb-2004-5-10-r80
摘要: The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and widespread use of innovative software, reducing barriers to entry into interdisciplinary scientific research, and promoting the achievement of remote reproducibility of research results. We describe details of our aims and methods, identify current challenges, compare Bioconductor to other open bioinformatics projects, and provide working examples.

24. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

被引: 11993 | 年份: 2012 | 语言: en
期刊: The Lancet
作者: Stephen S Lim, Theo Vos, Abraham D Flaxman, Goodarz Danaei, Kenji Shibuya
DOI: https://doi.org/10.1016/s0140-6736(12)61766-8
摘要:

25. Internet of Things (IoT): A vision, architectural elements, and future directions

被引: 11979 | 年份: 2013 | 语言: en
期刊: Future Generation Computer Systems
作者: Jayavardhana Gubbi, Rajkumar Buyya, Slaven Marusic, Marimuthu Palaniswami
DOI: https://doi.org/10.1016/j.future.2013.01.010
摘要:

26. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

被引: 11509 | 年份: 2016 | 语言: en
期刊: European Heart Journal
作者: Piotr Ponikowski, Adriaan A. Voors, Stefan D. Anker, Héctor Bueno, John G. F. Cleland
DOI: https://doi.org/10.1093/eurheartj/ehw128
摘要: No abstract available.

27. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

被引: 11158 | 年份: 2018 | 语言: en
期刊: Journal of Extracellular Vesicles
作者: Clotilde Théry, Kenneth W. Witwer, Elena Aïkawa, María José Alcaraz, Johnathon D. Anderson
DOI: https://doi.org/10.1080/20013078.2018.1535750
摘要: The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective

28. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

被引: 11073 | 年份: 2020 | 语言: en
期刊: Journal of the American College of Cardiology
作者: Gregory A. Roth, George A. Mensah, Catherine O. Johnson, Giovanni Addolorato, Enrico Ammirati
DOI: https://doi.org/10.1016/j.jacc.2020.11.010
摘要: Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) i

29. Open Babel: An open chemical toolbox

被引: 11056 | 年份: 2011 | 语言: en
期刊: Journal of Cheminformatics
作者: Noel M. O’Boyle, Michael Banck, Craig A. James, Chris Morley, Tim Vandermeersch
DOI: https://doi.org/10.1186/1758-2946-3-33
摘要: BACKGROUND: A frequent problem in computational modeling is the interconversion of chemical structures between different formats. While standard interchange formats exist (for example, Chemical Markup Language) and de facto standards have arisen (for example, SMILES format), the need to interconvert formats is a continuing problem due to the multitude of different application areas for chemistry data, differences in the data stored by different formats (0D versus 3D, for example), and competition between software along with a lack of vendor-neutral formats. RESULTS: We discuss, for the first time, Open Babel, an open-source chemical toolbox that speaks the many languages of chemical data. Open Babel version 2.3 interconverts over 110 formats. The need to represent such a wide variety of ch

30. PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews

被引: 10975 | 年份: 2021 | 语言: en
期刊: BMJ
作者: Matthew J. Page, David Moher, Patrick M. Bossuyt, Isabelle Boutron, Tammy Hoffmann
DOI: https://doi.org/10.1136/bmj.n160
摘要: The PRISMA 2020 statement includes a checklist of 27 items to guide reporting of systematic reviews In this article we explain why reporting of each item is recommended, present bullet points that detail the reporting recommendations, and present examples from published reviews We hope that uptake of the PRISMA 2020 statement will lead to more transparent, complete, and accurate reporting of systematic reviews, thus facilitating evidence based decision making on 1 September